Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and …
The ubiquitously distributed MAP1S is a homologue of the exclusively neuronal distributed
microtubule-associated protein 1A and 1B (MAP1A/B). They give rise to multiple isoforms
through similar post-translational modification. Isoforms of MAP1S have been implicated in
microtubule dynamics and mitotic abnormalities and mitotic cell death. Here we show that
ablation of the Map1s gene in mice caused reduction in the B-cell CLL/lymphoma 2 or xL
(Bcl-2/xL) and cyclin-dependent kinase inhibitor 1B (P27) protein levels, accumulation of …
microtubule-associated protein 1A and 1B (MAP1A/B). They give rise to multiple isoforms
through similar post-translational modification. Isoforms of MAP1S have been implicated in
microtubule dynamics and mitotic abnormalities and mitotic cell death. Here we show that
ablation of the Map1s gene in mice caused reduction in the B-cell CLL/lymphoma 2 or xL
(Bcl-2/xL) and cyclin-dependent kinase inhibitor 1B (P27) protein levels, accumulation of …
