Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma
CM Leys, S Nomura, E Rudzinski, M Kaminishi… - Human pathology, 2006 - Elsevier
Metaplastic lineages represent critical putative preneoplastic precursors for gastrointestinal
metaplasia. Two metaplastic processes are associated with gastric cancer: intestinal
metaplasia (the presence of intestinal goblet cell containing lineages in the stomach) and
spasmolytic polypeptide–expressing metaplasia (SPEM; antralization of the gastric fundus).
The transcription factor Pdx-1 is expressed in the adult pancreatic islet cells as well as the
gastric antrum and duodenum. We have previously noted the increase in Pdx-1 expression …
metaplasia. Two metaplastic processes are associated with gastric cancer: intestinal
metaplasia (the presence of intestinal goblet cell containing lineages in the stomach) and
spasmolytic polypeptide–expressing metaplasia (SPEM; antralization of the gastric fundus).
The transcription factor Pdx-1 is expressed in the adult pancreatic islet cells as well as the
gastric antrum and duodenum. We have previously noted the increase in Pdx-1 expression …
