Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
Clinically-applicable protocols that promote tolerance to vascularized skin grafts may
contribute to more widespread use of composite tissue transplantation. We compared the
properties of alloantigen (Ag)-pulsed, rapamycin (Rapa)-conditioned and control bone
marrow-derived host myeloid dendritic cells (DCs) and their potential, together with transient
immunosuppression (anti-lymphocyte serum+ cyclosporine), to promote long-term,
vascularized skin graft survival in Lewis rats across a full MHC barrier. Both types of DCs …
contribute to more widespread use of composite tissue transplantation. We compared the
properties of alloantigen (Ag)-pulsed, rapamycin (Rapa)-conditioned and control bone
marrow-derived host myeloid dendritic cells (DCs) and their potential, together with transient
immunosuppression (anti-lymphocyte serum+ cyclosporine), to promote long-term,
vascularized skin graft survival in Lewis rats across a full MHC barrier. Both types of DCs …
