Pruritus induced by crude bile and purified bile acids: experimental production of pruritus in human skin
DP Varadi - Archives of dermatology, 1974 - jamanetwork.com
Crude bile, when applied to keratinstripped human skin in a cream vehicle at acid pH, under
occlusion, produced noticeable pruritus after a period of 15 to 17 hours. At neutral or
alkaline pH, no pruritus resulted. Purified, unconjugated sodium deoxycholate and
chenodeoxycholate in a cream vehicle at acid pH also produced pruritus. Purified cholate
sodium and sodium lithocholate, as well as synthetic straight chain anionic and neutral
detergents failed to induce pruritus under the same experimental conditions. In complete …
occlusion, produced noticeable pruritus after a period of 15 to 17 hours. At neutral or
alkaline pH, no pruritus resulted. Purified, unconjugated sodium deoxycholate and
chenodeoxycholate in a cream vehicle at acid pH also produced pruritus. Purified cholate
sodium and sodium lithocholate, as well as synthetic straight chain anionic and neutral
detergents failed to induce pruritus under the same experimental conditions. In complete …