Central mu-opioid receptors are down-regulated in a rat model of cholestasis
NV Bergasa, RB Rothman, J Vergalla, H Xu… - Journal of …, 1992 - Elsevier
Ameliorations of the pruritus of cholestasis by opioid antagonists are consistent with this
form of pruritus being centrally mediated by the opioid system. To determine whether the
central opioid system is altered in cholestasis, the specific binding of a selective mu-opioid
receptor ligand, 3 H-DAMGO, to mu-opioid receptors was studied in rats with acute
cholestasis due to bile duct resection. Using whole brain membranes and subcellular
mitochondrial-synaptosomal fractions the density of mu-receptor sites was 30%(p< 0.01) …
form of pruritus being centrally mediated by the opioid system. To determine whether the
central opioid system is altered in cholestasis, the specific binding of a selective mu-opioid
receptor ligand, 3 H-DAMGO, to mu-opioid receptors was studied in rats with acute
cholestasis due to bile duct resection. Using whole brain membranes and subcellular
mitochondrial-synaptosomal fractions the density of mu-receptor sites was 30%(p< 0.01) …