[HTML][HTML] Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury
D Hsu, M Fukata, YG Hernandez, JP Sotolongo… - Laboratory …, 2010 - Elsevier
Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands
implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4
(TLR4) induces intestinal epithelial cell (IEC) proliferation by activating EGFR through AR
expression. We examined whether TLR4 differentially regulates expression of EGFR ligands
in response to mucosal injury. The human IEC line SW480 was examined expression of
EGFR ligands, EGFR phosphorylation, and proliferation in response to lipopolysaccharide …
implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4
(TLR4) induces intestinal epithelial cell (IEC) proliferation by activating EGFR through AR
expression. We examined whether TLR4 differentially regulates expression of EGFR ligands
in response to mucosal injury. The human IEC line SW480 was examined expression of
EGFR ligands, EGFR phosphorylation, and proliferation in response to lipopolysaccharide …
