[HTML][HTML] Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts
S Verma, AM Shewan, JA Scott, FM Helwani… - Journal of biological …, 2004 - ASBMB
Classical cadherin adhesion molecules are fundamental determinants of cell-cell
recognition that function in cooperation with the actin cytoskeleton. Productive cadherin-
based cell recognition is characterized by a distinct morphological process of contact zone
extension, where limited initial points of adhesion are progressively expanded into broad
zones of contact. We recently demonstrated that E-cadherin ligation recruits the Arp2/3 actin
nucleator complex to the plasma membrane in regions where cell contacts are undergoing …
recognition that function in cooperation with the actin cytoskeleton. Productive cadherin-
based cell recognition is characterized by a distinct morphological process of contact zone
extension, where limited initial points of adhesion are progressively expanded into broad
zones of contact. We recently demonstrated that E-cadherin ligation recruits the Arp2/3 actin
nucleator complex to the plasma membrane in regions where cell contacts are undergoing …
