Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology
VL Burgio, G Ballardini, M Artini, M Caratozzolo… - Hepatology, 1998 - journals.lww.com
In this paper we show that in viral hepatitis most Kupffer cells (KCs) are activated and
express high levels of CD80, CD40, and class-II MHC molecules, thus acquiring the
phenotype of professional antigen presenting cells (APCs). Activated KCs display a close
contact with CD4+ T lymphocytes and form KCs-T lymphocyte clusters. Clusters are found
within the sinusoids, across the sinusoid wall, and within the liver parenchima as well, as a
consequence of transendothelial migration (TEM). The positivity of activated KCs for …
express high levels of CD80, CD40, and class-II MHC molecules, thus acquiring the
phenotype of professional antigen presenting cells (APCs). Activated KCs display a close
contact with CD4+ T lymphocytes and form KCs-T lymphocyte clusters. Clusters are found
within the sinusoids, across the sinusoid wall, and within the liver parenchima as well, as a
consequence of transendothelial migration (TEM). The positivity of activated KCs for …
