Involvement of glutamate receptors in strychnine-and bicuculline-induced allodynia in conscious mice
M Onaka, T Minami, I Nishihara, S Ito - The Journal of the American …, 1996 - pubs.asahq.org
Background Glycine and gamma-aminobutyric acid (GABA) are inhibitory neurotransmitters
that appear to be important in sensory processing in the spinal dorsal horn. Intrathecal
administration of strychnine (strychnine-sensitive glycine receptor antagonist) or bicuculline
(GABAA antagonist) was reported to induce allodynia. Although the strychnine-induced
allodynia was shown to be mediated through the N-methyl-D-aspartate (NMDA)-type
glutamate receptor, it is not clear whether the bicuculline-evoked-allodynia is mediated …
that appear to be important in sensory processing in the spinal dorsal horn. Intrathecal
administration of strychnine (strychnine-sensitive glycine receptor antagonist) or bicuculline
(GABAA antagonist) was reported to induce allodynia. Although the strychnine-induced
allodynia was shown to be mediated through the N-methyl-D-aspartate (NMDA)-type
glutamate receptor, it is not clear whether the bicuculline-evoked-allodynia is mediated …
