It is generally accepted that the principal resident progenitor underlying regenerative capacity in skeletal muscle is the satellite cell. Satellite cells are present throughout life even though regenerative capacity declines with age and disease. Recently, other stem cell populations have been identified that can participate in muscle growth and regeneration. These cells may provide therapeutically useful sources of muscle stem cells as an alternative to satellite cells; however, the roles of these nonsatellite cell populations during muscle homeostasis, regeneration, and aging are unclear. Here, we discuss how the stem cell neighborhood influences satellite cell behavior and bring together recent discoveries pertaining to a wide variety of adult stem cells, including muscle stem cells and their niche.