[HTML][HTML] Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell …
DQ Guo, LW Wu, JD Dunbar, ON Ozes, LD Mayo… - Journal of Biological …, 2000 - ASBMB
Vascular endothelial cell growth factor (VEGF) binds to and promotes the activation of one of
its receptors, KDR. Once activated, KDR induces the tyrosine phosphorylation of cytoplasmic
signaling proteins that are important to endothelial cell proliferation. In human umbilical vein
endothelial cells (HUVECs), tumor necrosis factor (TNF) inhibits the phosphorylation and
activation of KDR. The ability of TNF to diminish VEGF-stimulated KDR activity was impaired
by sodium orthovanadate, suggesting that the inhibitory activity of TNF was mediated by a …
its receptors, KDR. Once activated, KDR induces the tyrosine phosphorylation of cytoplasmic
signaling proteins that are important to endothelial cell proliferation. In human umbilical vein
endothelial cells (HUVECs), tumor necrosis factor (TNF) inhibits the phosphorylation and
activation of KDR. The ability of TNF to diminish VEGF-stimulated KDR activity was impaired
by sodium orthovanadate, suggesting that the inhibitory activity of TNF was mediated by a …
