Identification of target genes of the transcription factor HNF1β and HNF1α in a human embryonic kidney cell line
S Senkel, B Lucas, L Klein-Hitpass, GU Ryffel - Biochimica et Biophysica …, 2005 - Elsevier
Hepatocyte nuclear factor 1beta (HNF1β, TCF2) is a tissue-specific transcription factor
whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy
and maturity onset diabetes of the young (MODY5). Furthermore, HNF1β overexpression
has been observed in clear cell cancer of the ovary. To identify potential HNF1β target
genes whose activity may be deregulated in human patients, we established a human
embryonic kidney cell line (HEK293) expressing HNF1β conditionally. Using Flp …
whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy
and maturity onset diabetes of the young (MODY5). Furthermore, HNF1β overexpression
has been observed in clear cell cancer of the ovary. To identify potential HNF1β target
genes whose activity may be deregulated in human patients, we established a human
embryonic kidney cell line (HEK293) expressing HNF1β conditionally. Using Flp …
