[HTML][HTML] SSeCKS/Gravin/AKAP12 Inhibits Cancer Cell Invasiveness and Chemotaxis by Suppressing a Protein Kinase C-Raf/MEK/ERK Pathway 2
B Su, Y Bu, D Engelberg, IH Gelman - Journal of Biological Chemistry, 2010 - ASBMB
SSeCKS/Gravin/AKAP12 (" SSeCKS") encodes a cytoskeletal protein that regulates G 1→ S
progression by scaffolding cyclins, protein kinase C (PKC) and PKA. SSeCKS is down-
regulated in many tumor types including prostate, and when re-expressed in MAT-LyLu
(MLL) prostate cancer cells, SSeCKS selectively inhibits metastasis by suppressing
neovascularization at distal sites, correlating with its ability to down-regulate proangiogenic
genes including Vegfa. However, the forced re-expression of VEGF only rescues partial lung …
progression by scaffolding cyclins, protein kinase C (PKC) and PKA. SSeCKS is down-
regulated in many tumor types including prostate, and when re-expressed in MAT-LyLu
(MLL) prostate cancer cells, SSeCKS selectively inhibits metastasis by suppressing
neovascularization at distal sites, correlating with its ability to down-regulate proangiogenic
genes including Vegfa. However, the forced re-expression of VEGF only rescues partial lung …
