Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse
NM Breese, AC George, LE Pauers, CL Stucky - Pain, 2005 - Elsevier
C-fiber nociceptors can be divided into two groups based on growth factor dependency and
isolectin B4 (IB4) binding. IB4-negative nociceptors have been proposed to contribute to
inflammatory pain. Since the TRPV1 receptor is critical for inflammatory heat hyperalgesia,
we hypothesized that inflammation would sensitize IB4 negative but not IB4-positive small-
diameter neurons to TRPV1 stimuli. Two days after complete Freund's adjuvant (CFA)-
induced inflammation in the hind paw of mice, lumbar 4/5 ganglia were dissociated and …
isolectin B4 (IB4) binding. IB4-negative nociceptors have been proposed to contribute to
inflammatory pain. Since the TRPV1 receptor is critical for inflammatory heat hyperalgesia,
we hypothesized that inflammation would sensitize IB4 negative but not IB4-positive small-
diameter neurons to TRPV1 stimuli. Two days after complete Freund's adjuvant (CFA)-
induced inflammation in the hind paw of mice, lumbar 4/5 ganglia were dissociated and …