Ionizing radiation exposure of skin results in a cutaneous radiation reaction comprising all
pathophysiological reactions and clinical symptoms in irradiated skin. Biological responses
of skin occur in a characteristic temporal pattern and mainly depend on radiation quality,
dose rate, total dose, and cellular conditions. Immediately after irradiation, production of
cytokines by skin cells is initiated and continues as a cascade during all stages of the
cutaneous radiation syndrome leading to progressive late symptoms, the predominant of …