Neurodegenerative diseases are generally characterized by the selective degeneration of
particular neuronal populations and the accumulation of abnormal or aggregated proteins
within, but occasionally external to, neurons in affected brain regions. These diseases can
be broadly classified as disorders of cognition and memory or movement, and both features
can often coexist in a single disease. In recent years, the identification of genetic mutations
that cause rare monogenic familial disease has revolutionized our understanding of the …