[HTML][HTML] Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation
Y Zhang, Z Dong, M Nomura, S Zhong, N Chen… - Journal of Biological …, 2001 - ASBMB
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and
UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis.
The upstream signaling pathways leading to p70 S6K phosphorylation and activation are
not well understood. Here, we observed that UVA induces phosphorylation and activation of
p70 S6K. Further, UVA-stimulated p70 S6K activity and phosphorylation at Thr 389 were
blocked by wortmannin, rapamycin, PD98059, SB202190, and dominant negative mutants …
UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis.
The upstream signaling pathways leading to p70 S6K phosphorylation and activation are
not well understood. Here, we observed that UVA induces phosphorylation and activation of
p70 S6K. Further, UVA-stimulated p70 S6K activity and phosphorylation at Thr 389 were
blocked by wortmannin, rapamycin, PD98059, SB202190, and dominant negative mutants …