Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression
A Nasef, C Mazurier, S Bouchet, S François… - Cellular …, 2008 - Elsevier
The interactions between mesenchymal stem cells (MSCs) and immune system are currently
being explored. Leukemia inhibitory factor (LIF) is linked to regulatory transplantation
tolerance. Our aim was to study the expression of LIF on human MSCs at both gene and
protein level in mixed lymphocyte reaction (MSC/MLR), and its implication in MSC
immunosuppressive effect. There was a 7-fold increase (611pg/ml) in LIF in MSC/MLR as
compared to MSCs alone. Using LIF neutralizing antibody, a significant restoration of up to …
being explored. Leukemia inhibitory factor (LIF) is linked to regulatory transplantation
tolerance. Our aim was to study the expression of LIF on human MSCs at both gene and
protein level in mixed lymphocyte reaction (MSC/MLR), and its implication in MSC
immunosuppressive effect. There was a 7-fold increase (611pg/ml) in LIF in MSC/MLR as
compared to MSCs alone. Using LIF neutralizing antibody, a significant restoration of up to …