Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex
PJ Conn, E Sanders-Bush - Neuropharmacology, 1984 - Elsevier
PJ Conn, E Sanders-Bush
Neuropharmacology, 1984•ElsevierEvidence suggests that the serotonin 5HT-1 receptor site is functionally linked to adenylate
cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2
receptor site has not been found. In the present paper we report an investigation of 5HT
stimulated phosphatidylinositol (PI) hydrolysis in rat cerebral cortex and have found that
selective 5HT-2 antagonists (pizotifen and ketanserin) block 5HT's effect upon PI
metabolism. These data suggest that 5HT stimulated PI hydrolysis is mediated by the 5HT-2 …
cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2
receptor site has not been found. In the present paper we report an investigation of 5HT
stimulated phosphatidylinositol (PI) hydrolysis in rat cerebral cortex and have found that
selective 5HT-2 antagonists (pizotifen and ketanserin) block 5HT's effect upon PI
metabolism. These data suggest that 5HT stimulated PI hydrolysis is mediated by the 5HT-2 …
Abstract
Evidence suggests that the serotonin 5HT-1 receptor site is functionally linked to adenylate cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2 receptor site has not been found. In the present paper we report an investigation of 5HT stimulated phosphatidylinositol (PI) hydrolysis in rat cerebral cortex and have found that selective 5HT-2 antagonists (pizotifen and ketanserin) block 5HT's effect upon PI metabolism. These data suggest that 5HT stimulated PI hydrolysis is mediated by the 5HT-2 binding site.
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