FOXP3: not just for regulatory T cells anymore
SF Ziegler - European journal of immunology, 2007 - Wiley Online Library
SF Ziegler
European journal of immunology, 2007•Wiley Online LibraryThe forkhead family transcription factor FOXP3 has been shown to be critical for the
development and function of CD4+ CD25+ regulatory T cells. Recently, FOXP3 expression
has been shown to be induced upon activation of human CD4+ T cells. A new report in this
issue of the European Journal of Immunology shows that expression of FOXP3 in activated T
cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function.
This finding suggests a new role for FOXP3 in human CD4+ T cells: down‐modulating …
development and function of CD4+ CD25+ regulatory T cells. Recently, FOXP3 expression
has been shown to be induced upon activation of human CD4+ T cells. A new report in this
issue of the European Journal of Immunology shows that expression of FOXP3 in activated T
cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function.
This finding suggests a new role for FOXP3 in human CD4+ T cells: down‐modulating …
Abstract
The forkhead family transcription factor FOXP3 has been shown to be critical for the development and function of CD4+CD25+ regulatory T cells. Recently, FOXP3 expression has been shown to be induced upon activation of human CD4+ T cells. A new report in this issue of the European Journal of Immunology shows that expression of FOXP3 in activated T cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function. This finding suggests a new role for FOXP3 in human CD4+ T cells: down‐modulating responses to TCR‐mediated stimulation.
See accompanying article http://dx.doi.org/10.1002/eji.200636435
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