Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
PR Pine, B Chang, N Schoettler, ML Banquerigo… - Clinical …, 2007 - Elsevier
Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory
cells, is essential for immune complex-mediated signal transduction initiated by activated
receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and
potent small molecule Syk inhibitor suppressed clinical arthritis, bone erosions, pannus
formation, and synovitis. Serum anti-collagen type II antibody levels were unaltered, while
the half-life of exogenous antibody was extended when co-administered with R406 …
cells, is essential for immune complex-mediated signal transduction initiated by activated
receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and
potent small molecule Syk inhibitor suppressed clinical arthritis, bone erosions, pannus
formation, and synovitis. Serum anti-collagen type II antibody levels were unaltered, while
the half-life of exogenous antibody was extended when co-administered with R406 …
