Plasma concentrations of high-mobility group box protein 1, soluble receptor for advanced glycation end-products and circulating DNA in patients with acute …
AK Kocsis, A Szabolcs, P Hofner, T Takács, G Farkas… - Pancreatology, 2009 - Elsevier
Aims: High-mobility group box protein 1 (HMGB1), a late-acting proinflammatory cytokine, is
secreted actively by inflammatory cells, and released passively from necrotic cells. From the
aspect that both inflammation and necrosis are involved in the pathogenesis in acute
pancreatitis, the aim of the study was a joint investigation of the plasma concentrations of
HMGB1, its soluble receptor for advanced glycation end-products (sRAGE), and the
circulating DNA as a marker of cell death. Methods: 62 patients with acute pancreatitis (30 …
secreted actively by inflammatory cells, and released passively from necrotic cells. From the
aspect that both inflammation and necrosis are involved in the pathogenesis in acute
pancreatitis, the aim of the study was a joint investigation of the plasma concentrations of
HMGB1, its soluble receptor for advanced glycation end-products (sRAGE), and the
circulating DNA as a marker of cell death. Methods: 62 patients with acute pancreatitis (30 …
