Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans
F Zhang, HA Moniz, B Walcott, KW Moremen… - Biochimie, 2013 - Elsevier
Abstract Roundabout 1 (Robo1) is the cognate receptor for secreted axon guidance
molecule, Slits, which function to direct cellular migration during neuronal development and
angiogenesis. The Slit2–Robo1 signaling is modulated by heparan sulfate, a sulfated linear
polysaccharide that is abundantly expressed on the cell surface and in the extracellular
matrix. Biochemical studies have further shown that heparan sulfate binds to both Slit2 and
Robo1 facilitating the ligand–receptor interaction. The structural requirements for heparan …
molecule, Slits, which function to direct cellular migration during neuronal development and
angiogenesis. The Slit2–Robo1 signaling is modulated by heparan sulfate, a sulfated linear
polysaccharide that is abundantly expressed on the cell surface and in the extracellular
matrix. Biochemical studies have further shown that heparan sulfate binds to both Slit2 and
Robo1 facilitating the ligand–receptor interaction. The structural requirements for heparan …
