Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
R Nassini, M Gees, S Harrison, G De Siena… - Pain®, 2011 - Elsevier
Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism
underlying these bothersome and dose-limiting adverse effects is unknown. We
hypothesized that the transient receptor potential ankyrin 1 (TRPA1), a cation channel
activated by oxidative stress and cold temperature, contributes to mechanical and cold
hypersensitivity caused by oxaliplatin and cisplatin. Oxaliplatin and cisplatin evoked …
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism
underlying these bothersome and dose-limiting adverse effects is unknown. We
hypothesized that the transient receptor potential ankyrin 1 (TRPA1), a cation channel
activated by oxidative stress and cold temperature, contributes to mechanical and cold
hypersensitivity caused by oxaliplatin and cisplatin. Oxaliplatin and cisplatin evoked …
