Ca2+ transients in myenteric glial cells during the colonic migrating motor complex in the isolated murine large intestine
MJ Broadhead, PO Bayguinov… - The Journal of …, 2012 - Wiley Online Library
The Journal of physiology, 2012•Wiley Online Library
Non‐technical summary A ganglionated neural plexus, the myenteric plexus, within the
colon generates a propagating contraction called the colonic migrating motor complex
(CMMC) that underlies faecal pellet propulsion. Neurons in the myenteric plexus are
surrounded by a network of enteric glia cells (EGCs), which were traditionally thought to be
the glue that held the neurons together. Using imaging techniques, we demonstrate that
36% of EGCs respond with prolonged Ca2+ transients following their activation by excitatory …
colon generates a propagating contraction called the colonic migrating motor complex
(CMMC) that underlies faecal pellet propulsion. Neurons in the myenteric plexus are
surrounded by a network of enteric glia cells (EGCs), which were traditionally thought to be
the glue that held the neurons together. Using imaging techniques, we demonstrate that
36% of EGCs respond with prolonged Ca2+ transients following their activation by excitatory …
Non‐technical summary A ganglionated neural plexus, the myenteric plexus, within the colon generates a propagating contraction called the colonic migrating motor complex (CMMC) that underlies faecal pellet propulsion. Neurons in the myenteric plexus are surrounded by a network of enteric glia cells (EGCs), which were traditionally thought to be the glue that held the neurons together. Using imaging techniques, we demonstrate that 36% of EGCs respond with prolonged Ca2+ transients following their activation by excitatory nerve fibres that generate the CMMC, suggesting that EGCs are innervated and are activated during the CMMC.
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