[HTML][HTML] Conserved properties of human and bovine prion strains on transmission to guinea pigs
The first transmissions of human prion diseases to rodents used guinea pigs (Gps, Cavia
porcellus). Later, transgenic mice expressing human or chimeric human/mouse PrP
replaced Gps, but the small size of the mouse limits some investigations. To investigate the
fidelity of strain-specific prion transmission to Gps, we inoculated 'type 1'and 'type 2'prion
strains into Gps, and we measured the incubation times and determined the strain-specified
size of the unglycosylated, protease-resistant (r) PrP Sc fragment. Prions passaged once in …
porcellus). Later, transgenic mice expressing human or chimeric human/mouse PrP
replaced Gps, but the small size of the mouse limits some investigations. To investigate the
fidelity of strain-specific prion transmission to Gps, we inoculated 'type 1'and 'type 2'prion
strains into Gps, and we measured the incubation times and determined the strain-specified
size of the unglycosylated, protease-resistant (r) PrP Sc fragment. Prions passaged once in …