[HTML][HTML] Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive …
LMA Al-Huseini, HXA Yeang, S Sethu… - Journal of Biological …, 2013 - ASBMB
Nrf2 is a redox-responsive transcription factor that has been implicated in the regulation of
DC immune function. Loss of Nrf2 results in increased co-stimulatory molecule expression,
enhanced T cell stimulatory capacity, and increased reactive oxygen species (ROS) levels in
murine immature DCs (iDCs). It is unknown whether altered immune function of Nrf2-
deficient DCs (Nrf2−/− iDCs) is due to elevated ROS levels. Furthermore, it is unclear which
intracellular signaling pathways are involved in Nrf2-mediated regulation of DC function …
DC immune function. Loss of Nrf2 results in increased co-stimulatory molecule expression,
enhanced T cell stimulatory capacity, and increased reactive oxygen species (ROS) levels in
murine immature DCs (iDCs). It is unknown whether altered immune function of Nrf2-
deficient DCs (Nrf2−/− iDCs) is due to elevated ROS levels. Furthermore, it is unclear which
intracellular signaling pathways are involved in Nrf2-mediated regulation of DC function …