[HTML][HTML] Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated …
M Kim, L Song, J Moon, ZYJ Sun, A Bershteyn… - Journal of Biological …, 2013 - ASBMB
Structural characterization of epitope-paratope pairs has contributed to the understanding of
antigenicity. By contrast, few structural studies relate to immunogenicity, the process of
antigen-induced immune responses in vivo. Using a lipid-arrayed membrane-proximal
external region (MPER) of HIV-1 glycoprotein 41 as a model antigen, we investigated the
influence of physicochemical properties on immunogenicity in relation to structural
modifications of MPER/liposome vaccines. Anchoring the MPER to the membrane via an …
antigenicity. By contrast, few structural studies relate to immunogenicity, the process of
antigen-induced immune responses in vivo. Using a lipid-arrayed membrane-proximal
external region (MPER) of HIV-1 glycoprotein 41 as a model antigen, we investigated the
influence of physicochemical properties on immunogenicity in relation to structural
modifications of MPER/liposome vaccines. Anchoring the MPER to the membrane via an …