[HTML][HTML] Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and-resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle …
AJ Powell, J Tomberg, AM Deacon, RA Nicholas… - Journal of biological …, 2009 - ASBMB
Penicillin-binding protein 2 (PBP2) from N. gonorrhoeae is the major molecular target for β-
lactam antibiotics used to treat gonococcal infections. PBP2 from penicillin-resistant strains
of N. gonorrhoeae harbors an aspartate insertion after position 345 (Asp-345a) and 4-8
additional mutations, but how these alter the architecture of the protein is unknown. We have
determined the crystal structure of PBP2 derived from the penicillin-susceptible strain FA19,
which shows that the likely effect of Asp-345a is to alter a hydrogen-bonding network …
lactam antibiotics used to treat gonococcal infections. PBP2 from penicillin-resistant strains
of N. gonorrhoeae harbors an aspartate insertion after position 345 (Asp-345a) and 4-8
additional mutations, but how these alter the architecture of the protein is unknown. We have
determined the crystal structure of PBP2 derived from the penicillin-susceptible strain FA19,
which shows that the likely effect of Asp-345a is to alter a hydrogen-bonding network …