[HTML][HTML] Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine in anaplastic large cell lymphoma
MR Hassler, A Klisaroska, K Kollmann, I Steiner… - Biochimie, 2012 - Elsevier
DNA methylation is an epigenetic mechanism establishing long-term gene silencing during
development and cell commitment, which is maintained in subsequent cell generations.
Aberrant DNA methylation is found at gene promoters in most cancers and can lead to
silencing of tumor suppressor genes. The DNA methyltransferase inhibitor 5-aza-2′-
deoxycytidine (5-aza-CdR) is able to reactivate genes silenced by DNA methylation and has
been shown to be a very potent epigenetic drug in several hematological malignancies. In …
development and cell commitment, which is maintained in subsequent cell generations.
Aberrant DNA methylation is found at gene promoters in most cancers and can lead to
silencing of tumor suppressor genes. The DNA methyltransferase inhibitor 5-aza-2′-
deoxycytidine (5-aza-CdR) is able to reactivate genes silenced by DNA methylation and has
been shown to be a very potent epigenetic drug in several hematological malignancies. In …