[HTML][HTML] The apical Na+/H+ exchanger isoform NHE3 is regulated by the actin cytoskeleton
K Kurashima, S D'Souza, K Szászi… - Journal of Biological …, 1999 - ASBMB
The epithelial isoform of the Na+/H+ exchanger, NHE3, associates with at least two related
regulatory factors called NHERF1/EBP50 and NHERF2/TKA-1/E3KARP. These factors in
addition interact with the cytoskeletal protein ezrin, which in turn binds to actin. The possible
linkage of NHE3 with the cytoskeleton prompted us to test the effect of actin-modifying
agents on NHE3 activity. Cytochalasins B and D and latrunculin B, which interfere with actin
polymerization, induced a profound inhibition of NHE3 activity. The effect was isoform …
regulatory factors called NHERF1/EBP50 and NHERF2/TKA-1/E3KARP. These factors in
addition interact with the cytoskeletal protein ezrin, which in turn binds to actin. The possible
linkage of NHE3 with the cytoskeleton prompted us to test the effect of actin-modifying
agents on NHE3 activity. Cytochalasins B and D and latrunculin B, which interfere with actin
polymerization, induced a profound inhibition of NHE3 activity. The effect was isoform …