[HTML][HTML] cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rap1-dependent pathway
MR Vossler, H Yao, RD York, MG Pan, CS Rim… - Cell, 1997 - cell.com
MR Vossler, H Yao, RD York, MG Pan, CS Rim, PJS Stork
Cell, 1997•cell.comCyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth,
differentiation, and gene expression. We show here that cAMP can activate the transcription
factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP
kinase cascade. These cell type–specific actions of cAMP require the expression of the
serine/threonine kinase B-Raf and activation of the small G protein Rap1. Rap1, activated by
mutation or by the cAMP-dependent protein kinase PKA, is a selective activator of B-Raf and …
differentiation, and gene expression. We show here that cAMP can activate the transcription
factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP
kinase cascade. These cell type–specific actions of cAMP require the expression of the
serine/threonine kinase B-Raf and activation of the small G protein Rap1. Rap1, activated by
mutation or by the cAMP-dependent protein kinase PKA, is a selective activator of B-Raf and …
Abstract
Cyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth, differentiation, and gene expression. We show here that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP kinase cascade. These cell type–specific actions of cAMP require the expression of the serine/threonine kinase B-Raf and activation of the small G protein Rap1. Rap1, activated by mutation or by the cAMP-dependent protein kinase PKA, is a selective activator of B-Raf and an inhibitor of Raf-1. Therefore, in B-Raf-expressing cells, the activation of Rap1 provides a mechanism for tissue-specific regulation of cell growth and differentiation via MAP kinase.
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