T cell homeostasis: keeping useful T cells alive and live T cells useful
SC Jameson - Seminars in immunology, 2005 - Elsevier
Seminars in immunology, 2005•Elsevier
It has become clear that the regulation of T cell numbers is under peripheral homeostatic
control. However, the rules for homeostasis vary with the T cells' differentiation state and the
overall T cell number in the animal. Furthermore, homeostatic pressures can cause
unexpected changes in T cell differentiation and function which might promote or dampen T
cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions
in regulating the size and composition of the T cell pool.
control. However, the rules for homeostasis vary with the T cells' differentiation state and the
overall T cell number in the animal. Furthermore, homeostatic pressures can cause
unexpected changes in T cell differentiation and function which might promote or dampen T
cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions
in regulating the size and composition of the T cell pool.
It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells’ differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool.
Elsevier