Remyelination: the true regeneration of the central nervous system
AH Crawford, C Chambers, RJM Franklin - Journal of comparative …, 2013 - Elsevier
The myelin sheath, generated by oligodendrocytes in the central nervous system (CNS), is
crucial to neuronal function, enabling rapid propagation of nerve impulses and providing
trophic support to the axon. Remyelination is the default response to myelin damage.
Oligodendrocyte precursor cells, distributed throughout both the grey and white matter of the
CNS, are activated in response to myelin injury, undergoing proliferation, migration to the
site of damage and differentiation into mature myelinating oligodendrocytes. The end result …
crucial to neuronal function, enabling rapid propagation of nerve impulses and providing
trophic support to the axon. Remyelination is the default response to myelin damage.
Oligodendrocyte precursor cells, distributed throughout both the grey and white matter of the
CNS, are activated in response to myelin injury, undergoing proliferation, migration to the
site of damage and differentiation into mature myelinating oligodendrocytes. The end result …