Remyelination by transplanted oligodendrocytes of a demyelinated lesion in the spinal cord of the adult shiverer mouse
O Gout, A Gansmuller, N Baumann, M Gumpel - Neuroscience letters, 1988 - Elsevier
O Gout, A Gansmuller, N Baumann, M Gumpel
Neuroscience letters, 1988•ElsevierFragments of normal newborn mouse central nervous system (CNS) were transplanted into
the spinal cord of adult shiverer mice at distance of 1, 2 or 3 intervertebral spaces from a
lysolecithin-induced demyelinating lesion. Remyelination by grafted oligodendrocytes was
observed by electron microscopy (EM). This result showed the capability of grafted
oligodendrocytes or precursor cells to migrate to a demyelinated lesion and to remyelinate
naked axons in an adult host, even in presence of host spontaneous remyelination.
the spinal cord of adult shiverer mice at distance of 1, 2 or 3 intervertebral spaces from a
lysolecithin-induced demyelinating lesion. Remyelination by grafted oligodendrocytes was
observed by electron microscopy (EM). This result showed the capability of grafted
oligodendrocytes or precursor cells to migrate to a demyelinated lesion and to remyelinate
naked axons in an adult host, even in presence of host spontaneous remyelination.
Abstract
Fragments of normal newborn mouse central nervous system (CNS) were transplanted into the spinal cord of adult shiverer mice at distance of 1, 2 or 3 intervertebral spaces from a lysolecithin-induced demyelinating lesion. Remyelination by grafted oligodendrocytes was observed by electron microscopy (EM). This result showed the capability of grafted oligodendrocytes or precursor cells to migrate to a demyelinated lesion and to remyelinate naked axons in an adult host, even in presence of host spontaneous remyelination.
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