[HTML][HTML] Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding …
J Zhou, S Ye, T Fujiwara, SC Manolagas… - Journal of Biological …, 2013 - ASBMB
Iron is essential for osteoclast differentiation, and iron overload in a variety of hematologic
diseases is associated with excessive bone resorption. Iron uptake by osteoclast precursors
via the transferrin cycle increases mitochondrial biogenesis, reactive oxygen species
production, and activation of cAMP response element-binding protein, a critical transcription
factor downstream of receptor activator of NF-κB-ligand-induced calcium signaling. These
changes are required for the differentiation of osteoclast precursors to mature bone …
diseases is associated with excessive bone resorption. Iron uptake by osteoclast precursors
via the transferrin cycle increases mitochondrial biogenesis, reactive oxygen species
production, and activation of cAMP response element-binding protein, a critical transcription
factor downstream of receptor activator of NF-κB-ligand-induced calcium signaling. These
changes are required for the differentiation of osteoclast precursors to mature bone …