Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway

JC Gigliotti, L Huang, H Ye, A Bajwa… - Journal of the …, 2013 - journals.lww.com
AKI affects both quality of life and health care costs and is an independent risk factor for
mortality. At present, there are few effective treatment options for AKI. Here, we describe a
nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-
reperfusion injury in mice, which is a model for human AKI. We exposed anesthetized mice
to an ultrasound protocol 24 hours before renal ischemia. After 24 hours of reperfusion,
ultrasound-treated mice exhibited preserved kidney morphology and function compared with …