Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
ML Hamshere, P Bennett, N Williams… - Archives of general …, 2005 - jamanetwork.com
Context Traditionally, the search for genes involved in predisposition to major psychoses
has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin
data suggest that, in addition to genes with specificity for these phenotypes, there exist
genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and
schizoaffective disorder. Objective To undertake, to our knowledge, the first systematic
search for such loci. Design Genomewide linkage scan. Setting Affected individuals were …
has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin
data suggest that, in addition to genes with specificity for these phenotypes, there exist
genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and
schizoaffective disorder. Objective To undertake, to our knowledge, the first systematic
search for such loci. Design Genomewide linkage scan. Setting Affected individuals were …