Changes in cortical thickness during the course of illness in schizophrenia

NEM Van Haren, HG Schnack, W Cahn… - Archives of general …, 2011 - jamanetwork.com
Context Whether cortical thickness changes in schizophrenia over time are more
pronounced relative to the changes that can be attributed to normal aging has not been
studied. Objective To compare patients with schizophrenia and healthy control participants
on cortical thickness change. Design A 5-year longitudinal study comparing schizophrenic
patients and healthy controls using 2 magnetic resonance images of the brain. Setting
Patients were recruited from the Department of Psychiatry at the University Medical Centre …