Objective Gammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T
lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are
highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the
role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease. Methods
We found that the percentages of γδ T cells are increased in ApoE−/− mice fed a Western
diet. We generated TCRδ−/− ApoE−/− mice and fed them either rodent chow or a Western …