c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia
B Xia, C Tian, S Guo, L Zhang, D Zhao, F Qu, W Zhao… - Leukemia research, 2015 - Elsevier
Acute myeloid leukemia (AML) is a malignant and aggressive disease not sensitive to
chemotherapy. The dynamic interaction between AML cells and bone marrow (BM)
microenvironment plays a critical role in response of this disease to chemotherapy. It is
reported that mesenchymal stromal cells (MSC) are essential component of bone marrow
microenvironment which affects the survival of AML cells. The aim of our research is to
elucidate the mechanism of drug resistance of AML cells associated with MSC. We found …
chemotherapy. The dynamic interaction between AML cells and bone marrow (BM)
microenvironment plays a critical role in response of this disease to chemotherapy. It is
reported that mesenchymal stromal cells (MSC) are essential component of bone marrow
microenvironment which affects the survival of AML cells. The aim of our research is to
elucidate the mechanism of drug resistance of AML cells associated with MSC. We found …