Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

L Keir, RJM Coward - Pediatric nephrology, 2011 - Springer
L Keir, RJM Coward
Pediatric nephrology, 2011Springer
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic
syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the
different mechanistic pathways that lead to this histological picture in the kidney. It will focus
on atypical HUS and complement dysregulation, but will also highlight some other recent
advances in our understanding of this condition, including the potential role of the molecule
vascular endothelial growth factor-A (VEGF-A).
Abstract
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).
Springer