Measuring left ventricular pressure in late embryonic and neonatal mice
VP Le, A Kovacs, JE Wagenseil - JoVE (Journal of Visualized Experiments), 2012 - jove.com
Blood pressure increases significantly during embryonic and postnatal development in
vertebrate animals. In the mouse, blood flow is first detectable around embryonic day (E)
8.51. Systolic left ventricular (LV) pressure is 2 mmHg at E9. 5 and 11 mmHg at E14. 52. At
these mid-embryonic stages, the LV is clearly visible through the chest wall for invasive
pressure measurements because the ribs and skin are not fully developed. Between E14. 5
and birth (approximately E21) imaging methods must be used to view the LV. After birth …
vertebrate animals. In the mouse, blood flow is first detectable around embryonic day (E)
8.51. Systolic left ventricular (LV) pressure is 2 mmHg at E9. 5 and 11 mmHg at E14. 52. At
these mid-embryonic stages, the LV is clearly visible through the chest wall for invasive
pressure measurements because the ribs and skin are not fully developed. Between E14. 5
and birth (approximately E21) imaging methods must be used to view the LV. After birth …