Sorting nexins–unifying trends and new perspectives

J Carlton, M Bujny, A Rutherford, P Cullen - Traffic, 2005 - Wiley Online Library
J Carlton, M Bujny, A Rutherford, P Cullen
Traffic, 2005Wiley Online Library
The sorting nexins (SNXs) are a family of PX domain‐containing proteins found in yeast and
mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian
SNXs have been suggested to function variously in pro‐degradative sorting, internalization,
endosomal recycling, or simply in endosomal sorting. In yeast, the defining function for these
proteins is a regulation of cargo retrieval. Here we examine recent data on the SNX family of
proteins and attempt to draw out unifying themes between the work performed in yeast and …
The sorting nexins (SNXs) are a family of PX domain‐containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro‐degradative sorting, internalization, endosomal recycling, or simply in endosomal sorting. In yeast, the defining function for these proteins is a regulation of cargo retrieval. Here we examine recent data on the SNX family of proteins and attempt to draw out unifying themes between the work performed in yeast and mammalian systems.
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