[HTML][HTML] Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by Smads

LM Taylor, LM Khachigian - Journal of Biological Chemistry, 2000 - ASBMB
Transforming growth factor-β (TGF-β) regulates a diverse array of biological processes, such
as proliferation, differentiation, extracellular matrix production, and apoptosis. In cultured
vascular endothelial cells, TGF-β induces the expression of platelet-derived growth factor
(PDGF) B-chain, a mitogen and chemoattractant, at the level of transcription. The molecular
mechanism (s) underlying this process are not presently understood. In this study, we
performed serial 5′ deletion and transient transfection analysis to define a region in the …