Effect of chronic administration of tacrolimus and cyclosporine on human gastrointestinal permeability
G Parrilli, C Abazia, G Sarnelli, MM Corsaro… - Liver …, 2003 - journals.lww.com
The antirejection drug tacrolimus (FK506) has been reported to impair intestinal permeability
in an early stage after orthotopic liver transplantation (OLT), and cyclosporine (CsA) has
shown a similar effect in animals. We studied the chronic effect of FK506 and CsA on
gastroduodenal and intestinal permeability and on blood endotoxin levels in patients 2 to 3
years after OLT. Thirty-two OLT patients (22 men and 10 women; mean age, 44.8±7.1) who
had received CsA (n= 19) or FK506 (n= 13) and 10 healthy volunteers (6 male and 4 female …
in an early stage after orthotopic liver transplantation (OLT), and cyclosporine (CsA) has
shown a similar effect in animals. We studied the chronic effect of FK506 and CsA on
gastroduodenal and intestinal permeability and on blood endotoxin levels in patients 2 to 3
years after OLT. Thirty-two OLT patients (22 men and 10 women; mean age, 44.8±7.1) who
had received CsA (n= 19) or FK506 (n= 13) and 10 healthy volunteers (6 male and 4 female …