Stubborn Tregs limit T-cell therapy
CA Klebanoff, L Gattinoni - Blood, The Journal of the American …, 2012 - ashpublications.org
Blood, The Journal of the American Society of Hematology, 2012•ashpublications.org
In this issue of Blood, Baba and colleagues characterize a residual pool of CD4+ CD25+
Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that
undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy
(ACT) for the treatment of cancer. 1
Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that
undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy
(ACT) for the treatment of cancer. 1
In this issue of Blood, Baba and colleagues characterize a residual pool of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy (ACT) for the treatment of cancer. 1
ashpublications.org