Blood− brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

R Prakash, ST Carmichael - Current opinion in neurology, 2015 - journals.lww.com
R Prakash, ST Carmichael
Current opinion in neurology, 2015journals.lww.com
Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB
recovery and the evolution of individual cellular events associated with BBB change.
Neovascularization responses have been widely studied in stroke for their role in functional
recovery but the role of vascular reorganization after TBI in recovery is much less defined.
Summary
Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a long way; however, we lack a clear understanding of the course of BBB disruption and BBB recovery and the evolution of individual cellular events associated with BBB change. Neovascularization responses have been widely studied in stroke for their role in functional recovery but the role of vascular reorganization after TBI in recovery is much less defined.
Lippincott Williams & Wilkins