[HTML][HTML] Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model
KN Baden, J Murray, RA Capaldi, K Guillemin - Journal of biological …, 2007 - ASBMB
Deficiency of cytochrome c oxidase (COX) is associated with significant pathology in
humans. However, the consequences for organogenesis and early development are not
well understood. We have investigated these issues using a zebrafish model. COX
deficiency was induced using morpholinos to reduce expression of CoxVa, a structural
subunit, and Surf1, an assembly factor, both of which impaired COX assembly. Reduction of
COX activity to 50% resulted in developmental defects in endodermal tissue, cardiac …
humans. However, the consequences for organogenesis and early development are not
well understood. We have investigated these issues using a zebrafish model. COX
deficiency was induced using morpholinos to reduce expression of CoxVa, a structural
subunit, and Surf1, an assembly factor, both of which impaired COX assembly. Reduction of
COX activity to 50% resulted in developmental defects in endodermal tissue, cardiac …
