[HTML][HTML] Insulin-like growth factor 1 receptor signaling is required for optimal ATR-CHK1 kinase signaling in ultraviolet B (UVB)-irradiated human keratinocytes
MG Kemp, DF Spandau, R Simman… - Journal of Biological …, 2017 - ASBMB
UVB wavelengths of light induce the formation of photoproducts in DNA that are potentially
mutagenic if not properly removed by the nucleotide excision repair machinery. As an
additional mechanism to minimize the risk of mutagenesis, UVB-irradiated cells also activate
a checkpoint signaling cascade mediated by the ATM and Rad3-related (ATR) and
checkpoint kinase 1 (CHK1) kinases to transiently suppress DNA synthesis and cell cycle
progression. Given that keratinocytes in geriatric skin display reduced activation of the …
mutagenic if not properly removed by the nucleotide excision repair machinery. As an
additional mechanism to minimize the risk of mutagenesis, UVB-irradiated cells also activate
a checkpoint signaling cascade mediated by the ATM and Rad3-related (ATR) and
checkpoint kinase 1 (CHK1) kinases to transiently suppress DNA synthesis and cell cycle
progression. Given that keratinocytes in geriatric skin display reduced activation of the …